金沙网址,金沙游艺场网址

Zhiping Xie

Prof.

  • Tel: +86-021-34204090
  • Email: zxie@sjtu.edu.cn

Education and Research Experience

  • 2014-Present    Shanghai Jiao Tong University, School of Life Sciences and Biotechnology, Professor
  • 2009-2014        Nankai University, School of Medicine, Associate Professor (PI)
  • 2008-2009        University of Michigan, Ann Arbor, Life Sciences Institute, Postdoc Fellow
  • 2001-2008        University of Michigan, Ann Arbor, Dept. of MCDB, Ph.D.
  • 1997-2001        Peking University, Dept. of Biochemistry and Molecular Biology, China Center for Economic Research, B. S. & B. A.

Research Interests

Autophagy

Autophagy is a major intracellular degradation pathway critical for the health maintenance of eukaryotes. As it is mediated by vesicular trafficking, the degradation capacity of autophagy far surpasses that of the proteasomal pathway. It is the only known pathway capable of eliminating entire organelles. The current explosion of autophagy research was ignited in the 90s by pioneering works of Daniel J. Klionsky and Yoshinori Ohsumi. The identification of autophagy-related (ATG) genes in yeast greatly facilitated the subsequent expansion of research into multicellular organisms and the exploration of the physiological functions of autophagy.

The central step in macroautophagy (the best documented form of autophagy) is the formation of autophagosomes, which are double-membrane vesicles responsible for the sequestration and transport of degradation targets. One main focus of our past and current research is the elucidation of the molecular mechanisms underlying the membrane dynamics during autophagosome formation. In addition, we have a general interest in the study of intracellular membrane trafficking and the application of mathematics in biology.

Selected Publications

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    Li D, Yang SG, He CW, Zhang ZT, Liang Y, Li H, Zhu J, Su X*, Gong Q*, Xie Z*. Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy. BMC Biol. 2020 Aug 28;18(1):107.

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    Zhu J, Zhang ZT, Tang SW, Zhao BS, Li H, Song JZ, Li D, Xie Z*. A Validated Set of Fluorescent-Protein-Based Markers for Major Organelles in Yeast (Saccharomyces cerevisiae). mBio. 2019 Sep 3;10(5). pii: e01691-19.

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    Zhu J, Deng S, Lu P, Bu W, Li T, Yu L*, Xie Z*. The Ccl1-Kin28 kinase complex regulates autophagy under nitrogen starvation. J Cell Sci. 2016 Jan1;129(1):135-44. 

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    Li D, Song JZ, Shan MH, Li SP, Liu W, Li H, Zhu J, Wang Y, Lin J, Xie Z*. A fluorescent tool set for yeast Atg proteins. Autophagy. 2015 Jun 3;11(6):954-60. 

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    Li D, Song JZ, Li H, Shan MH, Liang Y, Zhu J, Xie Z*. Storage lipid synthesis is necessary for autophagy induced by nitrogen starvation. FEBS Lett. 2015 Jan 16;589(2):269-76. 

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    Chen Y, Zhou F, Zou S, Yu S, Li S, Li D, Song J, Li H, He Z, Hu B, Björn LO, Lipatova Z, Liang Y*, Xie Z*, Segev N*. A Vps21 endocytic module regulates autophagy. Mol Biol Cell. 2014 Oct 15; 25(20):3166-77. 

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    Backues SK, Chen D, Ruan J, Xie Z*, Klionsky DJ*. Estimating the size and number of autophagic bodies by electron microscopy. Autophagy. 2014 Jan 1;10(1):155-64. 

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    Zou S, Chen Y, Liu Y, Segev N, Yu S, Liu Y, Min G, Ye M, Zeng Y, Zhu X, Hong B, Björn LO, Liang Y*, Li S* and Xie Z*. Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae. Traffic. 2013 Feb;14(2):233-46. 

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    Yang J, Zhao Y, Ma K, Jiang FJ, Liao W, Zhang P, Zhou J, Tu B, Wang L, Kampinga HH, Xie Z*, Zhu WG*. Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway. Autophagy. 2011 Jul;7(7):748-59. ) 

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    Yu ZQ, Ni T, Hong B, Wang HY, Jiang FJ, Zou S, Chen Y, Zheng XL, Klionsky DJ, Liang Y, Xie Z*. Dual Roles of Atg8−PE Deconjugation by Atg4 in Autophagy. Autophagy. 2012 Jun;8(6):883-92.