金沙网址,金沙游艺场网址

Chunlin Wan

Research Professor

  • Tel: +86-021-62833148
  • Email: clwan@sjtu.edu.cn
  • Address: Room 204,Little White House,1954 Hua Shan Road, Shanghai

Education and Research Experience

  • 1991/9-1995/7,    Nanjing Normal University                       B.S.
  • 1997/9-2000/7,    Nanjing Normal University                       M.S
  • 2000/9-2003/7,    Institute of Genetics and Development Biology,      Ph.D.
                                    Chinese Academy of Sciences    
  • 2003/9-2006/3,    Bio-X Institutes, Shanghai Jiao Tong University      Postdoctoral Fellow
  • 2006/3-2007/12,   Bio-X Institutes, Shanghai Jiao Tong University      Assistant Professor
  • 2008/1-2013/12,   Bio-X Institutes, Shanghai Jiao Tong University      Associate Professor
  • 2014/1-present,       Bio-X Institutes, Shanghai Jiao Tong University      Professor
  • 2010/5-2011/5,    Department of Biomedical Informatics,             Postdoctoral Fellow
                                   Vanderbilt University Medical Center                   

Research Interests

Molecular diagnosis of schizophrenia based on niacin skin reaction

Characteristics of niacin skin flushing reaction in Chinese psychiatric patients were revealed through our large-scale niacin skin reaction test, and a molecular diagnostic model of schizophrenia with high specificity and sensitivity was developed. Based on this phenomenon, we will focus on the niacin skin response signal pathway from the perspective of genetics, gene expression, protein expression, metabolite levels, etc., in order to reveal the mechanisms of niacin-blunted phenomenon in schizophrenia patients.

Molecular diagnosis of schizophrenia based on metabolic abnormalities

Through a GC/MS-based metabolomics study, we revealed the molecular characteristics of metabolic disturbance in patients with schizophrenia and constructed a well-functioning molecular diagnostic model. At this stage, we will systematically analyze the metabolic characteristics of patients with schizophrenia using proteomics, metabolomics, metagenomics, and bioinformatics analysis methods, focusing on fatty acid metabolism, bile acid metabolism, and intestinal microbial-related metabolism. Our goal is to explore the molecular mechanisms of metabolic abnormalities in patients with schizophrenia and develop reliable molecular markers for clinical diagnosis.

Study on the mechanism of redox imbalance in schizophrenia

Leukocyte proteomic profiling reveals the redox imbalance-centered molecular pathological features of schizophrenia, in which mitochondrial dysfunction and immune inflammatory response together cause elevated oxidative stress, and the antioxidant system and apoptosis is activated in patients with schizophrenia. The study of cell-free DNA also supports the activation of apoptosis in schizophrenia. Based on this, we will continue to carry out in-depth research on mitotic function, immune inflammation and apoptosis in schizophrenia to reveal the mechanism of oxidative stress involved in the development of schizophrenia, and provide strong support for elucidating the etiology of the disease.

Selected Publications

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    Jiang J, Peng C, Sun L, Li J, Hu X, Qing Y, Yang X, Li Y, Xu C, Zhang J, Min J, Li X, Qin S, Mei L, Tan L, Wan C. Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia? Antioxidant Redox Signaling. 2019 Sep 10;31(8):579-588. 

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    Xu C, Yang X, Sun L, Yang T, Cai C, Wang P, Jiang J, Qing Y, Hu X, Wang D, Wang P, Cui G, Zhang J, Li Y, Ji F, Liu C, and Wan C. An investigation of calcium-independent phospholipase A2 (iPLA2) and cytosolic phospholipase A2 (cPLA2) in schizophrenia, Psychiatry Research. 2019 Jan 29; 273: 782-87.

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    Jiang J, Chen X, Sun L, Qing Y, Yang X, Hu X, Yang C, Xu T, Wang J, Wang P, He L, Dong C, Wan C. Analysis of the concentrations and size distributions of cell-free DNA in schizophrenia using fluorescence correlation spectroscopy. Translational Psychiatry. 2018 May 22;8(1):104.

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    Sun L, Yang X, Jiang J, Hu X, Qing Y, Wang D, Yang T, Yang C, Zhang J, Yang P, Wang P, Cai C, Wang J, He L, Wan C. Identification of the niacin-blunted subgroup of schizophrenia patients from mood disorders and healthy individuals in Chinese population. Schizophrenia Bulletin. 2017 Oct 25; 44(4):896-907.

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    Yang X, Sun L, Zhao A, Hu X, Qing Y, Jiang J, Yang C, Wang P, Liu J, Zhang J, He L, Jia W, Wan C. Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study. Translational Psychiatry. 2017 Jul 25; 7(7): e1176.

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    Hu X, Du S, Yu J, Yang X, Yang C, Zhou D, Wang Q, Qin S, Yan X, He L, Han D, Wan C. Common housekeeping proteins are upregulated in colorectal adenocarcinoma and hepatocellular carcinoma, making the total protein a better "housekeeper". Oncotarget. 2016 Aug 20; doi: 10.18632.

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    Qing Y, Sun L, Yang C, Jiang J, Yang X, Hu X, Cui D, Xu Y, He L, Han D, Wan C. Dysregulated 14-3-3 family in peripheral blood leukocytes of patients with schizophrenia. Scientific Reports. 2016 Mar 31; 6:23791.

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    Sun L, Qing Y, Yang X, Yang C, Jiang J, Hu X, Ding J, He L, Tan L, Wan C. Gene expression profiling of the xMHC region reveals 9 candidate genes in schizophrenia. The Journal of Clinical Psychiatry. 2016 May 77; e597-599.

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    Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan, C. Potential metabolite markers of schizophrenia. Molecular Psychiatry. 2013 Jan; 18(1): 67~78.

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    Zhou K, Yang Y, Gao L, He G, Li W, Tang K, Ji B, Zhang M, Li Y, Yang J, Sun L, Zhao Z, Zhu H, He L, Wan C. NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism And Semaphorin Signaling in Rats: A Synaptic Proteome Study. Schizophrenia Bulletin. 2012 May; 38(3): 579-591.

Academic Rewards

  • 2008 Shanghai Jiao Tong University “SMC-Morning Star Young Scholars Award Scheme” , Category B
  • 2013 Shanghai Jiao Tong University “SMC-Morning Star Young Scholars Award Scheme” , Category A
  • National Natural Science Foundation of China, “Study on Cross-scale Phenotypic Characteristics of Schizophrenia and Construction of Related Networks” (2020-2023)
  • Shanghai Municipal Science and Technology Major Project “International Human Phenotype Group Plan (Phase I) “Study on Cross-scale Phenotypic Characteristics of Schizophrenia and Construction of Related Networks” (2019-2021)
  • Shanghai Jiao Tong University “Transformation Medicine Cross-Research Fund” Project “Effects of blastomere loss on offspring health and its mechanism during human early embryo freezing and thawing” (2019-2021)
  • Shanghai Jiao Tong University “Transformation Medicine Cross Research Fund” project “Molecular Diagnostic Technique for Schizophrenia Based on Niacin Skin Response” (2018-2020)
  • National Natural Science Foundation of China, “Study on Abnormal Fatty Acid Metabolism in Schizophrenia” (2018-2021)
  • Shanghai Jiao Tong University “Medical and Industrial Interdisciplinary Research Fund” project “The role of ENA78-related pathways in the pathogenesis of depression” (2017-2019)
  • National Key Research and Development Program "Biomarker for schizophrenia staging identification and construction of multi-level risk control system" (2016-2020)
  • National Key Research and Development Program “Study on Individualized Treatment Options for Antipsychotic Drugs” (2016-2020)
  • Shanghai Science and Technology Commission Key Research and Development Program "Children's Intellectual Development Disabilities Research Resource Bank"
  • (2016-2019)
  • National Natural Science Foundation of China, “Using Supergroup Method to Study Hepatic Metabolic Disorders in Mice Treating Antipsychotic Drugs” (2013-2016)
  • National Natural Science Foundation International (Regional) Cooperation and Exchange Project "Study on Brain Immunohistochemistry and Proteomics of Sp4 Gene Deficient Rats" (2013)
  • 973 Sub-Project "Modification of metabolically related proteins and their effects on metabolism" (2012-2016)
  • National Natural Science Foundation of China Youth Science Fund Project “Study on Protein Molecular Markers of Schizophrenia” (2008-2010)
  • 973 Sub-Project "Metabonomic Research of Common Mental Illness" (2006-2010)

Selected Grants

Students

  • Student
  • Graduates