报告题目: System approaches to understanding the mechanisms underpinning plant root architecture
报 告 人: Prof. Charlie Hodgman
Room C20 2nd Floor, Admin Building
School of Biosciences
The University of Nottingham
I have been promoting Integrative Systems Biology since I joined GlaxoWellcome in 1995, paying particular emphasis on the development of informatics approaches to turn what is an otherwise manual-developed "cottage industry" into an industrial process in which representative models can be generated automatically. This will be necessary if bio-systems modeling is to keep pace with the rate of data generation. Owing to my diverse background, I am not wedded to and particular branch of the life sciences and welcome collaborative projects where they are of most benefit, especially with industry.
Specific current projects include:
the development of dynamic models of plant root growth,
holistic network models of various organisms, including Arabidopsis, dog, cow, wheat, Haloferax and tea(!),
web services for network construction and feature detection and gene regulatory region analysis, and
software pipelines (1) to increase the productivity of biopharmaceutical development, (2) for elucidation of changes in biological function arising from single nucleotide polymorphisms, and (3) for in silico cDNA cloning from expressed sequence tags.